2013 Fiscal Year Final Research Report
Analyses of predictive factors from hepatitis to cirrhosis using metabolomics
| Project/Area Number |
24890126
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
MASAYA Saito 神戸大学, 医学部附属病院, その他 (00631558)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 肝硬変 / 肝線維化 |
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| Research Abstract |
Using liver biopsy, hepatitis was induced in mice with coline-deficient diet for 4 weeks, but not in mice without coline-deficient diet. Serum level of taurine decreased in mice with coline-deficient diet for 4 weeks. In mice with coline-deficient diet for 8 weeks, liver tissue showed cirrhosis from hepatitis.
In cirrhotic mice, moreover, serum level of taurine decreased compared with that of hepatitis mice. Therefore, serum taurine would negatively be associated with liver fibrosis in mice. In human as well as mice, serum level of taurine was negatively associated with liver fibrosis. We thought that serum level of taurine would be a predictive marker of liver fibrosis.
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Research Products
(16 results)
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[Journal Article] Mutational diversity of NS5A and NS3 during triple therapy (telaprevir, pegylated-interferon-α2b and ribavirin) for genotype 1b chronic hepatitis C : The Kobe Hepatitis Therapeutic Group2014
Author(s)
Fugui Bai, Yoshihiko Yano, Soo-Ryang Kim, Yasushi Seo, Akira Miki, Masaya Saito, Hirotaka Hirano, Kenji Momose, Akihiro Minami, Yuri Hatazawa, Takanobu Hayakumo, Dewiyani Widasari, Hanggoro Tri Rinonce, Masahiko Sugano, Satoshi Tani, Seitetsu Yoon, Susumu Imoto, Takeshi Azuma, Hak Hotta, Yoshitake Hayashi
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Journal Title
DOI
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[Journal Article] Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma2013
Author(s)
Fugui Bai, Yoshihiko Yano, Takumi Fukumoto, Atsushi Takebe, Motofumi Tanaka, Kaori Kuramitsu, Nungki Anggorowati, Hanggoro Tri Rinonce, Dewiyani Widasari, Masaya Saito, Hirotaka Hirano, Takanobu Hayakumo, Yasushi Seo, Takeshi Azuma, Yonson Ku, Yoshitake Hayashi
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Journal Title
Int J Hepatol
Pages: 849290
DOI
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[Journal Article] Ahmed El-Shamy, Hak Hotta, Yoshitake Hayashi, Kobe Hepatitis Therapeutic Group. Mutations in non-structural 5A and rapid viral response to pegylated interferon-α-2b plus ribavirin therapy are associated with therapeutic efficacy in patients with genotype 1b chronic hepatitis C2012
Author(s)
Yoshihiko Yano, Yasushi Seo, Akira Miki, Masaya Saito, Hirotaka Kato, Ken-Ichi Hamano, Manabu Oya, Sachiko Ouchi, Takashi Fujisawa, Hajime Yamada, Yukimasa Yamashita, Satoshi Tani, Shigeya Hirohata, Seitetsu Yoon, Naoto Kitajima, Kazunari Kitagaki, Akira Kawara, Takatoshi Nakashima, Hosai Yu, Tetsuo Maeda, Takeshi Azuma
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Journal Title
Int J Mol Med
Volume: 30(5)
Pages: 1048-1052
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