Assessment of three-dimensional micro-beam radiation therapy

2013 Fiscal Year Final Research Report

• Project/Area Number: 24890128
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: MUKUMOTO Naritoshi 神戸大学, 医学部附属病院, 特命技術員 (70634278)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Keywords: マイクロビームX線 / 放射光 / SPring-8 / シンクロトロン / 放射線治療

Research Abstract

Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in a single fraction using arrays of microplanar X-ray beams. Microplanar beam (MPB) radiation is, at present, an experimental approach that has produced, in single exposures, exceptionally high tolerance in the normal tissues while preferentially damaging malignant tumors. In this study, we have challenged to evaluate normal tissue tolerance and mortality by MPB radiation to mouse brain with comparing to broad beam from the same radiation source.
In the experimental setting, 50% and 100% lethal dose by the 200 micrometer spacing MPB beam were 600 Gy and 720Gy, while those by the broad beam were 80 Gy and 96 Gy. Beam paths by MPB irradiation were recognized as bands of cell with hyperchromatic. Micro or partial cerebral hemorrhage was shown in the dead mice brain from both groups.Our results indicated that the MPB enable to deliver extremely high doses without loss of normal tissue function.

Research Products

• [Journal Article] Patterns of failure after multimodal treatments for high-grade glioma : effectiveness of MIB-1 labeling index (2012)
  • Author(s): Uehara K, Sasayama T, Miyawaki D, Nishimura H, Yoshida K, Okamoto Y, Mukumoto N, Akasaka H, Nishihara M, Fujii O, Soejima T, Sugimura K, Kohmura E, Sasaki R
  • Journal Title: Radiation Oncology Volume: 7 Pages: 104
  • Peer Reviewed
• [Presentation] 眼瞼周囲皮膚癌に対する新規眼球シールド使用時の線量分布の検討 (2014)
  • Author(s): 椋本成俊,宮脇大輔,赤坂浩亮,王天縁,清水康之,上薗玄,吉田賢史,江島泰生,佐々木良平,吉田直碁,表田真弓,西谷隆治,南利明青,山裕一
  • Organizer: 第306回公益社団法人日本医学放射線学会関西地方会(第378回レントゲンアーベント)
  • Place of Presentation: 大阪、ホテルエルセラーン大阪
  • Year and Date: 2014-02-15
• [Presentation] A Novel method of Radioprotection for the Gastointestinal System : Efficacy of the Reduced form of Coenzyme Q10 (2013)
  • Author(s): Ryohei Sasaki, Nelly, Naritoshi Mukumoto, Hiroaki Akasaka, Nor Shazrina Sulaiman, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima
  • Organizer: 55th Annual meeting ASTRO
  • Place of Presentation: Atlanta, GA
  • Year and Date: 20130922-25
• [Presentation] A Novel Radiosensitizor of the Functional Food Component, Monogalactosyl diacylglycerol (MGDG) from Spinach, Enhanced the Cytotoxic Effects for the Pancreatic Cancer In Vitro and In Vivo (2013)
  • Author(s): H. Akasaka, R. Sasaki, N. Mukumoto, M. Nakayama, N.S. Sulaiman, D. Miyawaki, K. Yoshida, Y. Ejima, Y. Mizushina
  • Organizer: 55th Annual meeting ASTRO
  • Place of Presentation: Atlanta, GA
  • Year and Date: 20130922-25
• [Presentation] Normal tissue tolerance of microplanar beam X-ray : A long-term observation (2013)
  • Author(s): Naritoshi Mukumoto, Daisuke Miyawaki, Hiroaki Akasaka, Masao Nakayama, Yasushi Miura, Keiji Umetani, Nobuteru Nariyama, Kunio Shinohara, Takeshi Kondoh and Ryohei Sasaki
  • Organizer: 55th Annual meeting ASTRO
  • Place of Presentation: Atlanta, GA
  • Year and Date: 20130922-0925
• [Presentation] 鼻腔腫瘍の治療計画における不均質補正の影響 (2013)
  • Author(s): 椋本成俊、吉田賢史、赤坂浩亮、江島泰生、宮脇大輔、上薗玄、佐々木良平、大月直樹、丹生健一
  • Organizer: 第304回公益社団法人日本医学放射線学会関西地方会(第376回レントゲンアーベント)
  • Place of Presentation: 大阪、ホテルエルセラーン大阪
  • Year and Date: 2013-06-15
• [Presentation] Redox制御を介した放射線腸管障害抑制法の基礎的検討 (2012)
  • Author(s): NELLY,佐々木良平、椋本成俊、赤坂浩亮、、中山雅央、高山いずみ、西村英輝、吉田賢史、宮脇大輔
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 20121123-25
• [Presentation] 大型動物を用いた体内吸収性スペーサーの長期安全性の検討 (2012)
  • Author(s): 佐々木良平、赤坂浩亮、西村英輝、吉田賢史、宮脇大輔、中山雅央、椋本成俊、出水祐介、村上昌雄、福本巧
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 20121123-25
• [Presentation] マイクロスリットビームX線照射における最適条件の検討 (2012)
  • Author(s): 椋本成俊、佐々木良平、赤坂浩亮、中山雅央、NELLY、西村英輝、吉田賢史、三浦靖史、梅谷啓二
  • Organizer: 近藤威日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 20121123-25
• [Presentation] Efficacy of Surgically Implanted Flexible Spacer in Particle Therapy : A novel strategy Making Temporal Space between Tumor and Adjacent Organs (2012)
  • Author(s): Hiroaki Akasaka, Ryohei Sasaki, Takumi Fukumoto, Naritoshi Mukumoto, Masao Nakayama, Hideki Nishimura, Kenji Yoshida, Daisuke Miyawaki, Shigeru Yamada, and Masao Murakami
  • Organizer: ASTRO's 54th Annual Meeting
  • Place of Presentation: Boston
  • Year and Date: 20121028-1101
• [Presentation] Surgically Implanted Flexible Spacer in Particle Therapy : Making Temporal Space between Tumor and Adjacent Organs! (2012)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Takumi Fukumoto, Naritoshi Mukumoto, Hideki Nishimura, Kenji Yoshida, Daisuke Miyawaki, Shigeru Yamada, and Masao Murakami
  • Organizer: The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島国際会議場
  • Year and Date: 20120719-21
• [Presentation] Normal tissue tolerance of microbeam X-ray irradiation Naritoshi (2012)
  • Author(s): Mukumoto, Ryohei Sasaki, Hiroaki Akasaka, Masao Nakayama, Kenji Yoshida, Hideki Nishimura, Keiji Umetani, Takeshi Kondoh, Yasushi Miura, and Kunio Shinohara
  • Organizer: The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島国際会議場
  • Year and Date: 20120719-21