2013 Fiscal Year Final Research Report

Elucidation of of non-alcoholic steatohepatitis exacerbation mechanism by dental infection and effects of dental treatment

Research Project

Project/Area Number	24890138
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Hiroshima University
Principal Investigator	FURUSHO Hisako 広島大学, 医歯薬保健学研究院(歯), 助教 (00634461)
Project Period (FY)	2012-08-31 – 2014-03-31
Keywords	P.gingivalis / 歯性感染 / NASH / 免疫
Research Abstract	Effect of Porphyromonas gingivalis (P.g.) on non-alcoholic steatohepatitis (NASH) were examined. Various bacterial components (lipopolysaccharaide;LPS, flagellin and DNA) activate natural immune pathways through TLR2, 4, 5 and 9, resulting in upregulation of inflammatory cytokine expression and inflammasome activation . In fatty liver, showing upreglation TLR2 expression, the increased sensitivity of P.g.-LPS, which is TLR2 ligand, may cause stronger pathogenesis. Moreover, elimination of P.g.-odontogenic infection in P.g.-infected / high fat diet induced NASH mouse model reduced inflammatory cytokines expression and inflammatory cytokines expression and inflammatory cytokines expression and inflammation in liver. It indicates that dental therapy may have beneficial impact on management of NASH.

(2 results)