2013 Fiscal Year Final Research Report
Role of fatty acid binding proteins for regulation of neural plasticity
| Project/Area Number |
24890144
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YAMAMOTO YUI 山口大学, 医学(系)研究科(研究院), 助教 (80635087)
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| Research Collaborator |
OWADA Yuji 山口大学, 大学院医学系研究科, 教授 (20292211)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | FABP / 多価不飽和脂肪酸 / 高次脳機能 |
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| Research Abstract |
In this study, we examined the role of fatty asid binding proteins (FABPs) in the regulation of cellular signaling transduction, mainly by using FABP gene ablated mice. The following results have been so far obtained: 1. brain-type FABP (FABP7) and epidermal-type FABP (FABP5) are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation(Sharifi et al., Cell and Tissue Res 2013). 2. heart-type FABP (FABP3) gene ablation in mice resulted in altered cognitive and emotional behaviors with the decrease of PUFA uptake into the brain. Basal GABA release was significantly increased in the contex of FABP3 gene ablated mice, while glutamate release was significantly decreased compared with wild-type mice.
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[Journal Article] Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells2013
Author(s)
Sharifi, K., Ebrahimi, M., Kagawa, Y., Islam, A., Tuerxun, T., Yasumoto, Y., Hara, T., Yamamoto Y., Miyazaki, H., Tokuda, N., Yoshikawa, T. and Owada, Y
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Journal Title
Cell and Tissue Res
Volume: 354
Pages: 683-695
Peer Reviewed
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[Presentation] FABP3 deficiency in mouse placenta impaired fatty acid transport form mother to fetus2014
Author(s)
Islam, A., Sharifi, K., Ebrahimi, M., Kagawa, Y., Sawada, T., Yamamoto Y., Yasumoto, Y., Miyazaki, H., Suzuki, R. and Owada, Y
Organizer
第119回日本解剖学会総会・全国学術集会
Place of Presentation
自治医科大学、栃木
Year and Date
2014-03-28
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[Presentation] FABP7 is involved in epigenetic modification in astrocytes2013
Author(s)
Kagawa, Y., Yasumoto, Y., Sharifi, K., Ebrahimi, M., Islam, A., Miyazaki, H., Kawamura, S., Yamamoto Y., Yoshikawa, T., Kogo, H., Sato, S., Sugino, N., Fujimoto, T., Owada, Y
Organizer
第36回日本分子生物学会
Place of Presentation
神戸ポートピアホテル、神戸
Year and Date
2013-12-04
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[Presentation] Fatty acid binding protein 3 (FABP3) regulates cognitive function and anxiety behaviors2013
Author(s)
Yamamoto Y., Sharifi, K., Islam, A., Ebrahimi, M., Kagawa, Y., Yasumoto, Y., Miyazaki, H., Kawamura, S., Sawada, T., Tokuda, N., Fukunaga, K., Owada, Y
Organizer
Neuroscience 2013
Place of Presentation
San Diego, USA
Year and Date
2013-11-14
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[Presentation] FABP7 is expressed in astrocytes and regulates the excitatory synapse formation in mouse cerebral cortex2013
Author(s)
Ebrahimi, M., Sharifi, K., Kagawa, Y., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto Y., Sawada, T., Yoshikawa, T., Owada, Y
Organizer
Neuroscience 2013
Place of Presentation
San Diego, USA
Year and Date
2013-11-14
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[Presentation]2013
Author(s)
Yasumoto, Y., Sadahiro, H., Sharifi, K., Kagawa, Y., Ebrahimi, M., Islam, A., Miyazaki, H., Kawamura, S., Yamamoto Y., Sawada, T., Suzuki, M., Owada, Y
Organizer
Neuroscience 2013
Place of Presentation
San Diego, USA
Year and Date
2013-11-14
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[Presentation] Fatty acid-binding protein 7 (FABP7) regulates lipid raft formation in astrocytes2013
Author(s)
Kagawa, Y., Ebrahimi, M., Sharifi, K., Islam, A., Yasumoto, Y., Miyazaki, H., Kawamura, S., Yamamoto Y., Sawada, T., Tokuda, T., Kogo, H., Fujimoto, T., Yoshikawa, T., Owada, Y
Organizer
第86回日本生化学会大会
Place of Presentation
パシフィコ横浜、横浜
Year and Date
2013-09-13
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