2013 Fiscal Year Final Research Report
mutual analysis of intracellular signaling and morphological change in phagosome formation and maturation
| Project/Area Number |
24890154
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKI Nobukazu 香川大学, 医学部, 教授 (10202748)
MIYAKE Katusya 香川大学, 医学部, 准教授 (30219745)
EGAMI Youhei 香川大学, 医学部, 助教 (80432780)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | ファゴサイトーシス / Rabタンパク質 / 小胞輸送 |
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| Research Abstract |
Phagocytosis has a crucial role in immune defense and development. In this study, using multicolor living cell imaging, it is found that Rab35 is involved in Fc-gamma receptor mediated phagocytosis. Rab35 is localized in phagocytic cup and maturing phagosome. In maturing phagosome, Rab35 and its effecter molecule, MICAL-L1 are budding form phagosome as tubular structures. These results are suggesting that Rab35/ MICAL-L1 play roles in receptor recycling or antigen presentation in Fc-gamma mediated phagocytosis.
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