Development of novel therapeutics and elucidation of drug resistance mechanisms in oral squamous cell carcinoma

2013 Fiscal Year Final Research Report

• Project/Area Number: 24890174
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: NAGATA MASASHI 熊本大学, 医学部附属病院, 非常勤診療医師 (10635791)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Keywords: 口腔癌 / 薬剤耐性 / アポトーシス / 新規治療薬

Research Abstract

After establishment of CDDP-resistant oral squamous cell carcinoma(OSCC) cell line, we have presented the importance of cIAP2 is an apoptosis inhibitory protein in CDDP resistance of OSCC in the analysis result. Further, we have reported that it is a prognostic factor and,5-FU-sensitive factor expression cIAP2 leads to 5-FU resistance in OSCC previously. These things indicate the possibility of cIAP2 is the target factor of multi-drug resistance. By targeting cIAP2 in OSCC patients refractory to suppress the expression, it may be possible to enhance the effect of chemo-radiation therapy and improve survival. This result is in the middle of writing paper as currently.

Research Products

• [Journal Article] A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma (2014)
  • Author(s): Kawahara K, Nakayama H, Nagata M, Yoshida R, Hirosue A, Tanaka T, Nakagawa Y, Matsuoka Y, Kojima T, Takamune Y, Yoshitake Y, Hiraki A, Shinohara M
  • Journal Title: Journal of Oral Pathology and Medicine Volume: 43(3) Pages: 350-356
• [Journal Article] Overexpression of fibronectin confers cell adhesion-mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells (2014)
  • Author(s): Nakagawa Y, Nakayama H, Nagata M, Yoshida R, Kawahara K, Hirosue A, Tanaka T, Yuno A, Matsuoka Y, Kojima T, Yoshitake Y, Hiraki A, Shinohara M
  • Journal Title: International Journal of Oncology Volume: 44(4) Pages: 1376-1384
• [Presentation] Increased cIAP2 produces cisplatin resistance in a human oral squamous cell carcinoma cell line (2013)
  • Author(s): Masashi Nagata, Hideki Nakayama, Takuya Tanaka, Ryoji Yoshida, Yoshihiro Nakagawa, Kenta Kawahara, Yoshihiro Yoshitake, Akimitsu Hiraki, Masanori Shinohara
  • Organizer: 第72回日本癌学会学術総会,第71回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜,ロイトン札幌
  • Year and Date: 2013-10-03
• [Presentation] ヒト口腔扁平上皮癌細胞株を用いたCDDP耐性株の樹立とcIAP2の役割 (2013)
  • Author(s): 永田将士、中山秀樹、吉田遼司、川原健太、中川純泰、藤家稔久、田中拓也、吉武義泰、平木昭光、篠原正徳
  • Organizer: 第37回頭頸部癌学会
  • Place of Presentation: 京王プラザホテル・東京
  • Year and Date: 2013-06-12
• [Presentation] The possible role of cIAP2 in cross-resistance to cisplatin in 5-FU-resistant oral aquamous cell carcinoma (2012)
  • Author(s): Masashi Nagata, Hideki Nakayama, Takuya Tanaka, Ryoji Yoshida, Yoshihiro Nakagawa, Kenta Kawahara, Yoshihiro Yoshitake, Kazutoshi Ota, Akimitsu Hiraki, Masanori Shinohara
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2012-09-19