Novel therapy on sarcopenia by targeting Akt signaling

2013 Fiscal Year Final Research Report

• Project/Area Number: 24890178
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kagoshima University
• Principal Investigator: AKASAKI Yuichi 鹿児島大学, 医歯(薬)学総合研究科, 助教 (00631920)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Keywords: 骨格筋 / 老化 / シグナル伝達 / 糖尿病 / 脂質

Research Abstract

Akt1-mediated increase in muscle mass led to reductions in fat mass and hepatic steatosis in older animals, and corrected age-associated impairments in glucose metabolism. These results indicate that the loss of lean muscle mass is a significant contributor to the development of age-related metabolic dysfunction and that interventions that preserve or restore fast/glycolytic muscle may delay the onset of metabolic disease.

Research Products

• [Journal Article] Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism (2014)
  • Author(s): Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K
  • Journal Title: Aging Cell Volume: 13(1) Pages: 80-91
  • DOI: 10.1111/acel.12153
  • Peer Reviewed
• [Journal Article] Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptorβ-expressing macrophages (2012)
  • Author(s): Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
  • Journal Title: J Am Heart Assoc Volume: 1 Pages: e003079
  • DOI: 10.1161/JAHA.112.003079
  • Peer Reviewed
• [Journal Article] Waon therapy upregulates Hsp90 and leads to angiogenesis through the Akt-endothelial nitric oxide synthase pathway in mouse hindlimb ischemia (2012)
  • Author(s): Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C
  • Journal Title: Circ J Volume: 76(7) Pages: 1712-21
  • Peer Reviewed
• [Journal Article] Akt1-Mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial Infarction (2012)
  • Author(s): Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H
  • Journal Title: Circ Heart Fail Volume: 5 Pages: 116-125
  • Peer Reviewed
• [Presentation] 長期食事管理された後期高齢者の脈波伝播速度 (2014)
  • Author(s): 宮内孝浩,赤崎雄一,大石充
  • Organizer: 日本老年病学会九州地方会(第24回)
  • Place of Presentation: 産業医科大学.北九州市
  • Year and Date: 2014-03-08
• [Book] カレントテラピー白衣高血圧(低リスクと高リスク)の治療 (2014)
  • Author(s): 赤崎雄一,大石充
  • Total Pages: Vol.32, No.3.,52-56
  • Publisher: ライフメディコム,東京