Therapeutic potential of LDL apheresis including activation of receptor-interacting molecule in the management of peripheral artery disease

2013 Fiscal Year Final Research Report

• Project/Area Number: 24890189
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Yokohama City University
• Principal Investigator: IKEYA Yuko 横浜市立大学, 附属病院, 指導診療医 (60453049)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Keywords: シグナル伝達 / 脂質 / 循環器・高血圧 / 生体分子 / トランスレーショナルリサーチ

Research Abstract

Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney disease (CKD). Patients with CKD are reported to have a significant greater risk of CVD-associated mortality than that of the general population. Low-density lipoprotein (LDL) apheresis is a potentially valuable treatment applied to conventional therapy-resistant hypercholesterolemic patients with coronary artery disease and peripheral artery disease (PAD). Although previous and recent studies have suggested that LDL apheresis exerts beneficial effects on the peripheral circulation in dialysis patients suf- fering from PAD, probably through a reduction of not only serum lipids but also of inflammatory or coagulatory factors and oxidative stress, the precise molecular mechanisms underlying the long-term effects of LDL apheresis on the improvement of the peripheral circulation remains unclear and warrants further investigation, including a possible role of Ang II receptor-interacting molecule, ATRAP.

Research Products

• [Journal Article] Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein (2013)
  • Author(s): Matsuda M, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, Azushima K, Uneda K, Haku S, Tsurumi-Ikeya Y, Toya Y, Maeshima Y, Yamashita A, Umemura S
  • Journal Title: J Biol Chem Volume: 288 Pages: 19238-19249
  • DOI: 10.1074/jbc.M113.451054
  • Peer Reviewed
• [Journal Article] What can we expect from the binding characteristics of azilsartan, a newly available angiotensin II blocker, in hypertension? (2013)
  • Author(s): Tamura K, Ohsawa M, Kanaoka T, Maeda A, Azushima K, Uneda K, Wakui H, Azuma K, Tsurumi-Ikeya Y, Umemura S
  • Journal Title: Hypertens Res Volume: 36 Pages: 107-108
  • DOI: 10.1038/hr.2012.166
  • Peer Reviewed
• [Journal Article] Therapeutic potential of low-density lipoprotein apheresis in the management of peripheral artery disease in patients with chronic kidney disease (2013)
  • Author(s): Tamura K, Tsurumi-Ikeya Y, Wakui H, Maeda A, Ohsawa M, Azushima K, Kanaoka T, Uneda K, Haku S, Azuma K, Mitsuhashi H, Tamura N, Toya Y, Tokita Y, Kokuho T, Umemura S
  • Journal Title: Ther Apher Dial Volume: 17 Pages: 185-192
  • DOI: 10.1111/j.1744-9987.2012.01149.x
  • Peer Reviewed
• [Journal Article] Enhanced Ang receptor-associated protein in renal tubule suppresses Ang-dependent hypertension (2013)
  • Author(s): Wakui H, Tamura K, Masuda S, Tsurumi-Ikeya Y, Fujita M, Maeda A, Ohsawa M, Azushima K, Uneda K, Matsuda M, Kitamura K, Uchida S, Toya Y, Kobori H, Nagahama K, Yamashita A, Umemura S
  • Journal Title: Hypertension Volume: 61 Pages: 1203-1210
  • DOI: 10.1161/HYPERTENSIONAHA.111.00572
  • Peer Reviewed
• [Journal Article] The physiology and pathophysiology of a novel angiotensin receptor-binding protein ATRAP/Agtrap (2013)
  • Author(s): Tamura K, Wakui H, Maeda A, Dejima T, Ohsawa M, Azushima K, Kanaoka T, Haku S, Uneda K, Masuda S, Azuma K, Shigenaga A, Koide Y, Tsurumi-Ikeya Y, Matsuda M, Toya Y, Tokita Y, Yamashita A, Umemura S
  • Journal Title: Curr Pharm Des Volume: 19 Pages: 3043-3048
  • DOI: 10.2174/1381612811319170010
  • Peer Reviewed
• [Journal Article] Addition of aliskiren to Angiotensin receptor blocker improves ambulatory blood pressure profile and cardiorenal function better than addition of benazepril in chronic kidney disease (2013)
  • Author(s): Ohsawa M, Tamura K, Kanaoka T, Wakui H, Maeda A, Dejima T, Azushima K, Uneda K, Kobayashi R, Tsurumi-Ikeya Y, Toya Y, Fujikawa T, Umemura S
  • Journal Title: Int J Mol Sci Volume: 14 Pages: 15361-15375
  • DOI: 10.3390/ijms140815361
  • Peer Reviewed
• [Journal Article] Umemura S.L/N-type calcium channel blocker cilnidipine added to renin-angiotensin inhibition improves ambulatory blood pressure profile and suppresses cardiac hypertrophy in hypertension with chronic kidney disease (2013)
  • Author(s): Kanaoka T, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kobayashi R, Fujikawa T, Tsurumi-Ikeya Y, Maeda A, Yanagi M, Toya Y
  • Journal Title: Int J Mol Sci Volume: 14 Pages: 16866-16881
  • DOI: 10.3390/ijms140816866
  • Peer Reviewed
• [Journal Article] An increase in perfusion pressure and activation of the renin-angiotensin system in the pathogenesis of hypertension and injury : strain vessels and the cerebrovascular-renal connection (2012)
  • Author(s): Tamura K, Maeda A, Uneda K, Wakui H, Dejima T, Mitsuhashi H, Yamaguchi S, Tsurumi-Ikeya Y, Tokita Y, Umemura S
  • Journal Title: Hypertens Res Volume: 35 Pages: 972-974
  • DOI: 10.1038/hr.2012.108
  • Peer Reviewed
• [Journal Article] Genetic deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension
  • Author(s): Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, Azushima K, Uneda K, Tsurumi-Ikeya Y, Kobayashi R, Matsuda M, Uchida S, Toya Y, Kobori H, Nishiyama A, Yamashita A, Ishikawa Y, Umemura S
  • Journal Title: Kidney Int Volume: (in press)
  • DOI: 10.1038/ki.2014.95
  • Peer Reviewed
• [Journal Article] Effects of the angiotensin receptor blocker olmesartan on adipocyte hypertrophy and function in mice with metabolic disorders
  • Author(s): Maeda A, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kanaoka T, Kobayashi R, Ohki K, Matsuda M, Tsurumi-Ikeya Y, Yamashita A, Tokita Y, Umemura S
  • Journal Title: BioMed Res Int Volume: (in press)
  • DOI: 10.1155/2014/946492
  • Peer Reviewed
• [Remarks]
  • URL: http://www.yokohama-medicine.org