2013 Fiscal Year Final Research Report
Development of the novel biomarker for tissue damage using polyamines and their metabolites
| Project/Area Number |
24890195
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
UEMURA Takeshi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50401005)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | ポリアミン / アクロレイン / 肝臓 / アルコール / アセトアルデヒド / スペルミン酸化酵素 |
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| Research Abstract |
The objective of this research is to develop a novel test for the identification of the cause of death in legal autopsy cases. We found that alcohol consumption induced spermine oxidase (SMO) at the transcriptional level in the liver and generated acrolein by polyamine metabolism to exert cytotoxicity. Our results indicate that polyamines and acrolein levels in liver tissues can be used as a novel biomarker for tissue damage caused by alcohol consumption.
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Research Products
(6 results)
