2013 Fiscal Year Final Research Report
Neuronal feature of neonatal diabetes and investigation of neuronal feature of KATP channel in brain
| Project/Area Number |
24890218
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Keywords | KATPチャネル / 新生児糖尿病 / DEND症候群 |
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| Research Abstract |
The mutation which was used to generate transgenic mice showed toxicity on E coli. However, by using modified vector, ES screening was completed and now at the stage of injecting to the exbryo. The pharmacological regeneration of DEND status was committed by injecting KATP channel opener diazoxide to the rat brain. The injection successfully reproduced water intake disorder which is observed in DEND patient. In order to investigate possible new and effective treatment of DEND syndrome, the effect of pre-existing neurological drug on KATP channel activity was investigated. Ths study showed that antidepressant bupropion and antiepileptic drug valproic acid have inhibitory effect on KATP channel.
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