2013 Fiscal Year Final Research Report
Importance of UGT1A1 in breast milk-induced neonatal hyperbilirubinemia
| Project/Area Number |
24890224
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | ビリルビン / 新生児黄疸 / 薬物代謝酵素 / UGT1A1 / グルクロン酸抱合 |
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| Research Abstract |
UDP-Glucuronosyltransferase (UGT) 1A1 is the sole enzyme that can metabolize bilirubin. In the present study, we demonstrated that UGT1A1 is expressed not only in the liver and small intestine, but also in the skin. It was further demonstrated that oleic acid, linoleic acid, and docosahexaenoic acid (DHA), which are fatty acids included in the human breast milk, can strongly inhibit the UGT1A1 activity.
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