2013 Fiscal Year Final Research Report
Elucidation of the mechanism of cerebral blood flow based on redox regulation
| Project/Area Number |
24890225
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University (2013)
Kitasato University (2012) |
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Principal Investigator |
KURAUCHI Yuki 熊本大学, 大学院先導機構, 助教 (70631638)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | レドックス / 脳循環 |
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| Research Abstract |
The purpose of this study is to elucidate the mechanism of cerebral blood flow (CBF) based on redox regulation and search for the candidate medicine which improves CBF. In this study, the following was clarified.1) L-Citrulline improved the decrease in CBF during cortical spreading depression (CSD) via activation of nitric oxide (NO) signaling pathway.2) Activation of both MEK/ERK signaling pathway and calcineurin/NFAT signaling pathway contributes to the unusual increase in CBF and neuronal cell death induced by N-methyl-D-aspartate (NMDA).
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Research Products
(37 results)
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[Journal Article]2013
Author(s)
Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike A, Katsuki H
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Journal Title
Neuroscience
Volume: vol.231
Pages: 206-215
DOI
Peer Reviewed
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