2013 Fiscal Year Final Research Report

Exploring a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicator

Research Project

Project/Area Number	24890227
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pathological medical chemistry
Research Institution	Keio University
Principal Investigator	HASHIMOTO Hisayuki 慶應義塾大学, 医学部, 助教 (90528390)
Project Period (FY)	2012-08-31 – 2014-03-31
Keywords	細胞周期 / ライブイメージング / 心臓発生 / 再生医療
Research Abstract	The minimal capacity of mature cardiomyocte regeneration is one of the factors which determines the poor prognosis of heart failure. If we can proliferate cardiomyocytes and regenerate the heart, we will be able to completely cure heart failure. We planned to explore a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicator. We identified a protein which the expression level changes during the proliferation phase of cell cycle. We are analyzing the function of this candidate protein by over-expressing and deleting it in cardiomyocyte.