2013 Fiscal Year Final Research Report
Effects of volatile anesthetic on neural circuits in the mouse brain during postnatal development
| Project/Area Number |
24890234
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 吸入麻酔薬 / 脳内神経伝達 |
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| Research Abstract |
Volatile anesthetic sevoflurane, which is widely used in pediatric surgery, has proposed effects on GABAA receptor-mediated extrasynaptic tonic inhibition. In the developing striatum, medium-sized spiny projection neurons possess tonic GABA currents, which function in excitatory-inhibitory balance and maturation of striatal neural circuits. We examined effects of sevoflurane on the tonic GABA currents of medium spiny neurons in developing striatal slices. Sevoflurane strongly increased GABAA receptor-mediated tonic conductance at postnatal days 3 to 35. Antagonist of GABA transporter (GAT-1) NO-711 further increased tonic GABA conductance during the application of sevoflurane, thereby increasing total magnitude of tonic currents. Our findings suggest that sevoflurane can affect the tone of tonic GABA inhibition in a developing striatal neural network.
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