2013 Fiscal Year Final Research Report
Molecular mechanisms of amyloid beta metabolism by a cell survival factor
| Project/Area Number |
24890236
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Sophia University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Keywords | アルツハイマー病 / アミロイドベータ |
|---|
| Research Abstract |
Alzheimer's disease (AD) is the most common cause of dementia. Humanin (HN) is a novel neuroprotective factor and suppresses the neuronal death caused by AD-related insults in test tubes. A highly potent HN derivative ameliorated cognitive deficits and sustained the increase of amyloid burden in an AD mouse model, which exhibits complex AD-relevant pathology. In this study, we investigated the molecular mechanisms how HN suppresses amyloid accumulation, particularly focusing on an amyloid degradation enzyme and amyloid clearance by glial cells.
|
