• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Analysis of impact of blood metabolizing enzymes on the prediction brain blood concentration in midazolam sedation

Research Project

  • PDF
Project/Area Number 24890241
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionShowa University

Principal Investigator

NONAKA Mutsumi  昭和大学, 歯学部, 助教 (60635051)

Project Period (FY) 2012-08-31 – 2015-03-31
Keywords静脈内鎮静法 / プロポフォール / ミダゾラム / レミフェンタニル / 異常絞扼反射
Outline of Final Research Achievements

Excessive gagging reflex precludes dental treatment. Such patients need to sedate during treatment, though; patients are still resistant to the treatment even under sedation. Remifentanil(RF) is a short acting opiate, strongly suppressing reflex. We have tried to apply this agent to the patients with strong gagging reflex.
Six patients who had been resistant to suppression of gagging reflex by using midazolam(M) and propofol(P) were enrolled. Six patients were treated under sedation by using (P) and (RF). Treatments on the former sedation were unsuccessful, and all the latter sedation were successful. The treatment providers were satisfied with the smoothness of the treatment. (RF) there is a report that was effective in suppressing abnormal strangulation reflected by the combination with (P) or (M) I was applied to the intravenous sedation. Although amnesic effect was attenuated by reduction of (P), they tended not to affect much to the satisfaction of the patient.

Free Research Field

歯科麻酔科学

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi