2013 Fiscal Year Final Research Report
Role of CTGF/CCN2 in reparative dentin formation
| Project/Area Number |
24890258
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Keywords | 修復象牙質 / CTGF/CCN2 / BMP-1 / 象牙質・歯髄複合体 |
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| Research Abstract |
The aim of this study is to elucidate the expression and role of connective tissue growth factor/CCN family 2 (CTGF/CCN2) in reparative dentin formation. Results indicated that specific signal for CTGF/CCN2 and BMP-1 were increased in the layer of odontoblast-like cells subjacent to the dental caries in human teeth. BMP-1 was capable of inducing the expression of CTGF/CCN2 independently of protease activity in primary culture of human dental pulp cells. Exogenously added fluorescence-labeled BMP-1 was internalized into human dental pulp cells. Furthermore, a potent dynamin inhibitor clearly suppressed BMP-1-induced CCN2/CTGF expression. These findings indicate that novel mechanism of CTGF/CCN2 expression in reparative dentinogenesis.
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Research Products
(4 results)
