2013 Fiscal Year Final Research Report
Role of Schnurri-3 for immune response
| Project/Area Number |
24890297
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | 独立行政法人国立国際医療研究センター |
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Principal Investigator |
SEKI YOICHI 独立行政法人国立国際医療研究センター, 免疫制御研究部, 上級研究員 (80637059)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 免疫学 / シグナル伝達 / Schnurri-3 / ヘルパーT細胞 |
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| Research Abstract |
Schnurri-3 (Shn-3) is an essential molecule for the early stage of Th2 differentiation for regulation of IL-4 production by AP-1. Upon immunization with antigen, T cell-specific Shn-3 conditional knockout (Shn-3 TKO) mice had low IgE production compared to immunized control mice. Moreover, when CD4+CD62L+ naive T cells were cultured under condition to promote Th17 differentiation, Shn-3-deficient CD4+T cells differentiated to a Th17 phenotype more frequently than control CD4+T cells. Furthermore, Shn-3-TKO mice exhibited intense exacerbation of development and progression of T cell-mediated autoimmune disease EAE. These data suggest that Schnurri-3 plays an important role in determining the phenotype of helper T cells during an immunoresponse.
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