2013 Fiscal Year Final Research Report
The mechanism of aberrant gene expressions in adulthood caused by fetal and neonatal nutrition status.
| Project/Area Number |
24890299
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
TOMOKO Kawai 独立行政法人国立成育医療研究センター, 周産期病態研究部, 研究員 (40423404)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | エピゲノム / DNAメチル化 / 胎盤 |
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| Research Abstract |
In this study, we focused on human placental epigenetic regulation which might be affected by fetal growth restriction or gestational maternal weight gain. As a result, inadequate gestational weight gain augmented randomicity at epigenetic regulations even in placentas from normal birth weight. Furthermore, it is suggested that fetal growth restriction caused non-uniformity in epigenetic status independent from gestational weight gain.
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