The effect of APOE4 allele on cognitive decline in a general population of older Japanese.

2013 Fiscal Year Final Research Report

• Project/Area Number: 24890302
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: TANIGUCHI YU 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40636578)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Keywords: 認知機能低下 / アポリポタンパクE遺伝子多型 / 身体機能 / 栄養状態

Research Abstract

396 adults were reevaluated cognitive function during 1-year period, and cognitive decline was defined as decrease of two points or more on the Mini-Mental State Examination (MMSE) during follw-up. No significant difference was observed among APOE4 allele and cognitive decline. Gait function (maximum gait speed, step length) and nutritional biomarker (RBC,Alb,HDL-C) showed linear associations for cognitive decline after controlling for APOE4 allele and important confounders. Our findings indicate that APOE4 allele was not a risk marker of subsequent cognitive decline, and not a potential confounding variable between gait function or nutritional biomarker and cognitive decline.

Research Products

• [Journal Article] Nutritional Biomarkers and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese : A Prospective Study
  • Author(s): Yu Taniguchi、Shoji Shinkai、Mariko Nishi、Hiroshi Murayama、Yu Nofuji、Hiroto Yoshida、Yoshinori Fujiwara
  • Journal Title: The Journals of Gerontology Medical Science Volume: (in press)
  • DOI: 10.1093/Gerona/glt286
• [Journal Article] 群馬県草津町における介護予防10年間の取り組みと地域高齢者の身体,栄養,心理・社会機能の変化
  • Author(s): 清野諭、谷口優、吉田裕人、藤原佳典、天野秀紀、深谷太郎、西真理子、村山洋史、野藤悠、松尾恵理、干川なつみ、土屋由美子、新開省二
  • Journal Title: 日本公衆衛生雑誌 Volume: (印刷中)
• [Presentation] A Prospective Study of Health-Related Measures and Incidence of Frailty in a General Population of Older Japanese (2014)
  • Author(s): Yu Taniguchi、Shoji Shinkai、Yu Nofuji、Mariko Nishi、Hiroshi Murayama、Hidenori Amano、Satoshi Seino、Yuri Yokoyama
  • Organizer: 67th Annual Scientific Meeting in The Gerontological Society of America
  • Place of Presentation: Washington,D.C
  • Year and Date: 20141105-09
• [Presentation] 地域高齢者の健康余命に関するコホート研究(1)歩行機能との関連 (2014)
  • Author(s): 谷口優、西真理子、清野諭、藤原佳典、野藤悠、天野秀紀、村山洋史、松尾恵理、横山友里、新開省二
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20140612-14
• [Presentation] 高齢者における「世代間のふれ合いにともなう感情尺度」作成の試み-高齢者の心身の健康との関連に焦点をあてて- (2014)
  • Author(s): 村山陽,高橋知也,村山幸子,二宮知康,竹内瑠美,鈴木宏幸,野中久美子,谷口優,西真理子,新開省二,藤原佳典
  • Organizer: 第56回日本老年社会科学会
  • Place of Presentation: 岐阜
  • Year and Date: 20140607-08
• [Presentation] 地域在宅高齢者における3つの体力指標と要介護認定に関する前向きコホート研究 (2014)
  • Author(s): 谷口優、西真理子、藤原佳典、野藤悠、清野諭、天野秀紀、村山洋史、横山友里、吉田裕人、新開省二
  • Organizer: 第24回日本疫学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20140123-25
• [Presentation] A Prospective Study of Gait Performance and Cognitive Decline in a General Population of Older Japanese (2013)
  • Author(s): Yu Taniguchi、Shoji Shinkai、Hiroto Yoshida、Mariko Nishi、Hiroshi Murayama、Yu Nofuji、Yoshinori Fujiwara、Hayato Uchida
  • Organizer: 66th Annual Scientific Meeting in The Gerontological Society of America
  • Place of Presentation: New Orleans
  • Year and Date: 20131120-24
• [Presentation] MMSEにより評価する認知機能の低下の程度と要介護認定に関する前向きコホート研究 (2013)
  • Author(s): 谷口優、藤原佳典、西真理子、村山洋史、野藤悠、清野諭、天野秀紀、新開省二
  • Organizer: 第8回日本応用老年学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-11-09