2013 Fiscal Year Final Research Report
The study of aldosterone production machinery by angiotensin II metabolite
| Project/Area Number |
24890308
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Hiroshima University (2013)
Department of Clinical Research, National Hospital Organization Kure Medical Center (2012) |
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Principal Investigator |
OKI Kenji 広島大学, 大学病院, 病院助教 (30638995)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | アルドステロン / アンギオテンシンII / 高血圧 |
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| Research Abstract |
Aldosterone which regulates blood pressure is produced by angiotensin II (A-II) in zona glomerulosa of adrenal cortex. We previously demonstrated that the metabolite of A-II negatively regulated A-II mediated aldosterone production in human adrenocortical cancer cell line. In this study, we clarified that the metabolite was angiotensin 1-7 and it inhibit aldosterone production after A-II stimulation. The function of angiotensin 1-7 on aldosterone production was mediated by MAS receptor. We showed a new aldosterone production machinery via MAS receptor and our results might be useful for new target of anti-hypertensive agents.
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