2017 Fiscal Year Final Research Report
Design of Novel Biomaterials which Scavenge Reactive Oxygen Species and Their Applications
| Project/Area Number |
25220203
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-05-31 – 2018-03-31
|
| Keywords | ナノメディシン / ゲル / 抗酸化剤 / 再生医療 / アルツハイマー病 / 放射線保護 / バイオマテリアル / DDS |
|---|
| Outline of Final Research Achievements |
We designed "redox polymers" which selectively erase "bad" reactive oxygen species out of reactive oxygen species (ROS) which are double-edged sword, and developed innovative medical technology as new biomaterials. It was confirmed that by using redox polymer as a surface modification agent, contact activation of blood and tissues was suppressed, and nonspecific differentiation of stem cells was suppressed. At the same time, we attained the development of Alzheimer's and radiation protection materials by redox nanoparticles and the enhancement of the effect on anti-cancer and suppression of their side effects. We developed anti-oxidant injectable gel and developed it for periodontal disease, diabetes treatment, tissue adhesion prevention agent after surgical operation, etc. Such a polymerized antioxidant was able to demonstrate the usefulness that it can be deployed extremely widely.
|
| Free Research Field |
生体機能材料
|
