2017 Fiscal Year Final Research Report
Molecular architecture of vertebrate centromeres
| Project/Area Number |
25221106
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | Osaka University (2016-2017)
National Institute of Genetics (2013-2015) |
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Principal Investigator |
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| Research Collaborator |
HORI Tetsuya
NISHINO Tatsuya
HARA Masatoshi
TAKEUCHI Kozo
MAKINO Fumiaki
KAGAWA Naoko
FURUTA Maiko
SHANG Wei-Hao
PERPELESC Marinela
NAGPAL Harsh
|
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| Project Period (FY) |
2013-05-31 – 2018-03-31
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| Keywords | セントロメア / 染色体分配 / 細胞分裂 / エピジェネティックス / タンパク質複合体 |
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| Outline of Final Research Achievements |
The Centromere is a genomic locus, which is essential for faithful chromosome segregation. In this research project, we tried to clarify molecular basis how the centromere is formed and how centromere functions are controlled during progression of the cell cycle. We performed following 3 projects: (1) Analyses of centromere assembly using chromosome engineering techniques (2) In vitro reconstitution of centromere protein complexes (3) Structural analyses of centromere protein complexes at atomic resolution. All projects were going well, and our achievements in these projects contribute to understanding of molecular basis for centromere formation and functions.
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| Free Research Field |
分子細胞生物学
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