Synthetic Studies toward Large-scale production and Optimal Modification of Biologically Significant, Scarce Molecules

2017 Fiscal Year Final Research Report

• Project/Area Number: 25221301
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Chemical pharmacy
• Research Institution: Nagoya University
• Principal Investigator: Fukuyama Tohru 名古屋大学, 創薬科学研究科, 特任教授 (10272486)
• Co-Investigator(Kenkyū-buntansha): 藤間 達哉 名古屋大学, 創薬科学研究科, 助教 (70733971) ; 下川 淳 名古屋大学, 創薬科学研究科, 助教 (60431889) ; 横島 聡 名古屋大学, 創薬科学研究科, 准教授 (10376593)
• Project Period (FY): 2013-05-31 – 2018-03-31
• Keywords: 全合成 / 生体機能分子 / 量的供給 / 構造会へ念 / 天然有機化合物

Outline of Final Research Achievements

There is an urgent need for the supply of reliable drugs for treatment of cancer and dementia in Japan. In this research, biologically important natural products are taken up in order to seek for a seed for drug development. The purpose is to establish a novel and robust synthetic pathway for total synthesis of natural products, which allows their structural modification to synthesize a more potent and selective drug candidate. Efficient synthetic pathways were successfully established and they were applied for preparation of the analogues.

Free Research Field

全合成