Identification of Cellular Signaling Mechanism that regulates inflammation and tissue repairing

2017 Fiscal Year Final Research Report

• Project/Area Number: 25221305
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: YOSHIMURA Akihiko 慶應義塾大学, 医学部(信濃町), 教授 (90182815)
• Co-Investigator(Renkei-kenkyūsha): SEKIYA Takashi 慶應義塾大学, 医学部, 講師 (80519207) ; KIMURA Akihiro 慶應義塾大学, 医学部, 助教 (20533318) ; SHICHITA Takashi 慶應義塾大学, 医学部, 講師 (00598443)
• Project Period (FY): 2013-05-31 – 2018-03-31
• Keywords: サイトカイン / シグナル伝達 / 炎症 / マクロファージ / 制御性T細胞 / 組織障害 / 修復

Outline of Final Research Achievements

The immune system maintains homeostasis by positive and negative signaling, and dysregulation of thissytem leads to immune diseases such as allergies. This study aims to elucidate the basic principle of cytokines and their regulation which maintain the immune homeostasis, and to apply our findings to treatment of diseases. In this study, we found three important immunological factors that regulates the inflammatory responses. The first is NR4a transcription factors, which are necessary for the development and maintenance of regulatory T cells. The second is Smad transcription factors, which control the production of TGFβ, an immunosuppressive factor. The third is preparing macrophages which are involved in resolution of inflammation by clearing the factors released from dead cells.

Free Research Field

基礎医学・免疫学