2016 Fiscal Year Final Research Report
Development of new transformations based on transition metal-catalyzed alkylation and its applications
Project/Area Number |
25248025
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Synthetic chemistry
|
Research Institution | Osaka University |
Principal Investigator |
Kambe Nobuaki 大阪大学, 工学研究科, 教授 (60144432)
|
Project Period (FY) |
2013-05-31 – 2017-03-31
|
Keywords | クロスカップリング反応 / 多成分反応 / アルキル化反応 / 遷移金属触媒 |
Outline of Final Research Achievements |
This project was focused on the developments and applications of catalytic alkylation reactions. The significant achievements are as follows. Alkyl-alkyl cross-coupling reactions using Fe, Co, Ni, and Cu along with unsaturated hydrocarbon additives were developed and examined in detail. The Cu catalyst shows quite high catalytic activity, achieving more than 1 million TON. The Co catalyst enables cross-coupling of tertiary alkyl Grignard regents to construct quaternary carbon centers. Site-selective alkylation of 1,3-dienes at the internal carbon was achieved by Cu catalyst. Ni catalyst enables multicomponent coupling reactions of 1,3-butadiene. We succeeded in isolation of anionic Ni complexes, that have been proposed as the key catalytic intermediates in the cross-coupling reactions. Natural products containing a long alkyl chain were synthesized using Ni-catalysts. Another achievement includes development of chemical transformations of less reactive bonds such as C-F, C-O and C-H.
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Free Research Field |
合成化学
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