Construction of basic technologies to build up liposome integrated biosensor chip for diagnosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25249048
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Electron device/Electronic equipment
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: Noda Minoru 京都工芸繊維大学, 電気電子工学系, 教授 (20294168)
• Co-Investigator(Kenkyū-buntansha): 福澤 理行 京都工芸繊維大学, その他部局等, 准教授 (60293990) ; 寒川 雅之 新潟大学, 自然科学系, 助教 (70403128) ; 山下 馨 京都工芸繊維大学, 工芸科学研究科, 准教授 (40263230)
• Project Period (FY): 2013-10-21 – 2017-03-31
• Keywords: マイクロ・ナノデバイス / ナノバイオ / バイオデバイス / リポソーム / センサ / バイオセンサ

Outline of Final Research Achievements

In this research, basic technologies are proposed and investigated in order to build up the liposome integrated biosensor chip for diagnosis, based on our previous liposome biosensor and relating sensing technologies that made clear their operation principles. The research consists of three parts: I. Physical control of liposome supramolecule or its droplet, II. Challenge for realizing amyloidosis sensor, and III. Creation of information processing electronic system for array sensor signal. Especially, amyloid-beta is focused as biomarker of Altzheimer’s disease from important target biomolecules for diagnosis. Consequently, the aggregation and fibrilization of the protein was detected selectively in human serum by the developed liposome sensor. Also, the sensitivity was markedly improved as low as 1 nM by selecting proper lipid species and applying low noise electronic circuit techniques.

Free Research Field

集積デバイス工学