2015 Fiscal Year Final Research Report
Elucidation of structure-function linkage of the striatal input systems by means of various viral vectors
| Project/Area Number |
25250003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-10-21 – 2016-03-31
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| Keywords | 神経回路 / 大脳基底核 / 線条体 / ウイルスベクター / 霊長類 |
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| Outline of Final Research Achievements |
The present research project aims at elucidating the structure and function of neural networks related to the primate basal ganglia by establishing cutting-edge systems for neural network analyses with a variety of viral vectors. In the following three issues, the research plans set beforehand have successfully been progressed, and interesting outcomes concerning each issue have been achieved: (1) functional mapping of the striatum based on the patterns of multisynaptic outputs to the frontal lobe with high-efficiency multi-colored rabies viral vectors and of corticostriatal inputs, (2) input-output analyses of thalamic and nigral neurons projecting to a given region of the striatum, and (3) functional intervention in pathways linking the thalamus, nigra, and frontal lobe to a given region of the striatum.
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| Free Research Field |
神経科学
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