2018 Fiscal Year Final Research Report
Cortical oscillations dependent on pyramidal cell subtypes
Project/Area Number |
25250005
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | National Institute for Physiological Sciences |
Principal Investigator |
Kawaguchi Yasuo 生理学研究所, 基盤神経科学研究領域, 教授 (40169694)
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Project Period (FY) |
2013-04-01 – 2018-03-31
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Keywords | 前頭皮質 / ガンマ振動 / 錐体細胞 / 橋核投射細胞 / 交叉性線条体投射細胞 / FS細胞 / パルブアルブミン |
Outline of Final Research Achievements |
The integrative function of frontal cortex may rely on the synchronous firing of diverse neurons during oscillations. Fast-spiking (FS) cells, a subtype of inhibitory neurons, and thalamocortical inputs are supposed to play important roles in oscillation induction. For further understanding of cooperative activities among frontal cortical neurons, we analyzed thalamic inputs, synaptic connections with FS cells, and firing phases during oscillations in individual cortical cell subtypes. Consequently, we found cell subtype differences in thalamocortical inputs and firing phases during slow and gamma waves. Combined with local connection analysis, these findings suggest that individual FS cells do not selectively inhibit specific output subnetworks, but could synchronize diverse subcortical and corticocortical output channels in an integrative way.
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Free Research Field |
神経科学
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Academic Significance and Societal Importance of the Research Achievements |
脳は機能・局所回路が異なる多様な領域からできている。その中でも大脳皮質の前頭野は多くの皮質領野へ興奮性出力を送ることで、これらの活動を統合する役割を担うと考えられている。そのために、前頭野のパルブアルブミンという蛋白質を発現する抑制性細胞が局所回路接続と発火特性を特化させ、多様な投射パターンを持つ錐体細胞を制御し、出力信号の適切な組み合わせを正確なタイミングで他領域に送り出す可能性が高いことを本研究で見出した。
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