2015 Fiscal Year Final Research Report
Paradigm shift of mammalian mitochondrial genome using intercellular transfer technology
| Project/Area Number |
25250011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YONEKAWA Hiromichi 公益財団法人東京都医学総合研究所, 客員研究員 (30142110)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ミトコンドリアゲノム / ミトコンドリア移植 / 哺乳類 / 生理的役割 / 突然変異 / ミトコンドリア病 / がん化 / 老化関連疾患 |
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| Outline of Final Research Achievements |
The purpose of current proposal is to show the paradigm shift of two conventional concepts (paradigms A and B) regarding the roles of mammalian mitochondrial genome (mtDNA). Paradigm A is that the products of mtDNA are localized into mitochondrial inner membranes but not into cell membranes. The results of current study propose that the products of unknown cytoplasmic genetic factors but not the products of mtDNA are localized into cell membrane. Paradigm B is that the mutations in mtDNA are responsible not only for mitochondrial diseases, but also for aging and age-related disorders including tumor development. With respect to Paradigm B shift, we have proposed that aging phenotypes observed in elderly human fibroblasts are not caused by mtDNA mutations but by the reversible epigenetic regulations of nuclear-coded genes.
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| Free Research Field |
分子細胞生物学、哺乳類ミトコンドリアゲノム生物学
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