2015 Fiscal Year Final Research Report
Molecular mechanisms of biological regulation by endoplasmic reticulum stress response
| Project/Area Number |
25251014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 細胞内情報伝達機構 / 小胞体 / 発生・分化 / 疾患生物学 / ストレス |
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| Outline of Final Research Achievements |
Endoplasmic reticulum (ER) stress and its stress response play important roles in differentiation and maturation of various cells, and are also involved in onset of several diseases. In this research, we found that the signaling from the ER stress sensors activates vascularization in developmental bone tissues and is involved in differentiation of osteoclasts, and that the luminal domains of ER stress sensors are secreted from cells to extracellular spaces and facilitate cell proliferation through the activation of hedgehog signaling pathway. Further, we developed the method for inhibiting cell growth of cancer cells by application of monoclonal antibody against the luminal domain of ER stress sensors.
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| Free Research Field |
細胞生物学
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