2015 Fiscal Year Final Research Report
Molecular and functional properties of Opn5
| Project/Area Number |
25251036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAMOTO Yasushi 京都大学, 大学院理学研究科, 准教授 (80263200)
YAMASHITA Takahiro 京都大学, 大学院理学研究科, 助教 (50378535)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 光受容体 / オプシン / 機能多様性 / 分子メカニズム / モデル動物 |
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| Outline of Final Research Achievements |
Animal photoreceptor proteins, opsins, have been widely diversified to acquire various new physiological functions in the course of molecular evolution. In this study, we have investigated the molecular properties of opsins in Opn5 group, one of the opsin groups that was most recently discovered in mammals, and found that they were diversified into not only UV- and visible-light absorbing receptors but also a reverse photoreceptor that loses G protein activation activity by light. We have also investigated localizations of Opn5 in eyes and brain and explored their functions by generating knock-out medaka fishes. The results indicated that some of the Opn5 subgroups would be responsible for uncharacterized physiological functions. Furthermore, we have investigated the molecular properties of opsins diversified in the vertebrate visual opsin group to obtain insights into molecular mechanisms underlying diversification in Opn5 group.
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| Free Research Field |
分子生理学
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