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2017 Fiscal Year Final Research Report

Spatio-temporal regularory mechanisms of steroid uptake and transport in insect steroid hormone producing organs.

Research Project

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Project/Area Number 25252023
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioorganic chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

Kataoka Hiroshi  東京大学, 大学院新領域創成科学研究科, 教授 (60202008)

Research Collaborator OGIHARA Mari  学術振興会, RPD特別研究員
Project Period (FY) 2013-04-01 – 2017-03-31
Keywordsステロイド / コレステロール / 前胸腺 / カイコ
Outline of Final Research Achievements

LC-MS/MS analyses showed that cholesterol and 7-dehydrocholesterol increased with developmental growth in the prothoracic glands where the insect steroid hormone, ecdysone, was produced. The results of multivariate analysis of steroids compared with other tissues showed that the prothoracic glands have different steroid profiling from other tissues. Furthermore, the localization analyses of lipophorin, a steroid transport lipoprotein, and cholesterol also supported the existence of a steroid uptake mechanism unique to the prothoracic glands. We also could identify one scavenger receptor which might be a molecule involved in steroid uptake from lipophorin in the prothoracic glands.

Free Research Field

分子認識化学

URL: 

Published: 2019-03-29  

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