2016 Fiscal Year Final Research Report
Search for marine natural products that inhibit the pathway from metabolic syndrome to cadiovascular diseases
Project/Area Number |
25252037
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Aquatic life science
|
Research Institution | The University of Tokyo |
Principal Investigator |
Matsunaga Shigeki 東京大学, 大学院農学生命科学研究科(農学部), 教授 (60183951)
|
Co-Investigator(Kenkyū-buntansha) |
及川 勉 神奈川県立保健福祉大学, 保健福祉学部, 名誉教授 (40120141)
|
Co-Investigator(Renkei-kenkyūsha) |
IKEDA Megumi 神奈川県立保健福祉大学, 保健福祉学部, 助手 (90535402)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 脂肪細胞 / 分化誘導 / 海洋生物 / カイメン |
Outline of Final Research Achievements |
When appropriately differentiated, adipocytes secret proteins that can prevent metabolic syndromes. Therefore, compounds that promote the differentiation of preadipocytes to adipocytes are expected to improve the status of geriatric diseases. After searching for compounds with such activities, we found many active compounds from the marine sponge Xestspongia testudinaria and determined their structures. From other sponges we isolated a theonellamide related compound and an aromatic alkaloid as the active principles.
|
Free Research Field |
海洋天然物化学
|