2017 Fiscal Year Final Research Report
Role of myeloid-derived suppressor cells in tumor microenvironment
| Project/Area Number |
25252049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Murata Takahisa 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40422365)
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| Co-Investigator(Kenkyū-buntansha) |
有竹 浩介 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (70390804)
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| Project Period (FY) |
2013-05-31 – 2017-03-31
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| Keywords | がん / 脂質 / 炎症 |
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| Outline of Final Research Achievements |
Myeloid-derived suppressor cells are reported to modulate immunoresponses in tumor microenvironment. However, its detail charactaristics remain unknown.In the present project, we have revealed the anti-inflammatory role of myeloid-derived suppressor cells in tumor growth and metastasis using murine models. In detail, we evidenced that myeloid-derived suppressor cells produce anti-inflammatory lipid mediator prostaglandin D2 in tumor mass and metastatic tissue.
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| Free Research Field |
獣医薬理学
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