2016 Fiscal Year Final Research Report
Roles of extracellular environment and various cells carrying different function for cardiac fibrosis
Project/Area Number |
25253011
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
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Research Institution | Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
仲矢 道雄 九州大学, 薬学研究科(研究院), 准教授 (80464387)
長坂 明臣 九州大学, 薬学研究科(研究院), 助教 (10723877)
|
Project Period (FY) |
2013-10-21 – 2017-03-31
|
Keywords | 筋線維芽細胞 / 心筋梗塞 / 死細胞 / 抗炎症作用 / 免疫細胞 |
Outline of Final Research Achievements |
Heart often develops heart failure after myocardial infarction, if proper revascularization is not provided. Inflammatory responses are believed to be a factor to progress to heart failure after myocardial infarction. As inflammation is induced by the cellular components released from dead cells, the quick and efficient removal of dead cells in myocardial infarction is important for preventing the development of heart failure. So far, phagocytes such as macrophages and dendritic cells infiltrating infarct area are supposed to be the players of removing dead cells. In this study, myofibroblasts remove dead cell as well as phagocytes do. The removal of dead cells by myofibroblasts requires MFG-E8 that bridges between apoptotic cells and phagocytes. Thus, myofibroblasts remove dead cells after myocardial infarction, and suppress the progression to heart failure.
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Free Research Field |
循環薬理
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