2016 Fiscal Year Final Research Report
Inter-organ communication via the neuronal system in response to external environment
| Project/Area Number |
25253067
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
IZUMI Tomohito
ASAI Yoichiro
MUNAKATA Yuichiro
YAMAMOTO Junpei
SHIRAI Yuta
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 臓器連関 / 神経ネットワーク / 糖代謝 / 糖尿病 / 肥満 |
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| Outline of Final Research Achievements |
In multi-organ creatures, including human beings, inter-organ metabolic communication is essential to regulate systemic metabolism. We examined how the inter-organ communication functions in response to alterations in external environment.
Thereafter, we elucidated that 1) increased amino acid intake induces hypertriglyceridemia via a neuronal relay system, 2) hypoxic responses in steatotic liver are involved in gallstone formation, and 3) fatty acids promote glucose-stimulated insulin secretion via a newly-identified receptor family. Thus, a variety of inter-organ systems for metabolic homeostasis are ironically involved in obesity-related disorders.
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| Free Research Field |
糖尿病学
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