Development of a novel anti-invasion therapy targeting the glioma stem cell/endothelial cell invasion complex

2015 Fiscal Year Final Research Report

• Project/Area Number: 25253085
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Keio University
• Principal Investigator: Saya Hideyuki 慶應義塾大学, 医学部, 教授 (80264282)
• Co-Investigator(Kenkyū-buntansha): SAMPETREAN OLTEA 慶應義塾大学, 医学部, 特任助教 (50571113)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 細胞・組織 / 癌 / 発生・分化

Outline of Final Research Achievements

We have previously found that in glioblastoma, glioma stem cells can attract blood vessels from the normal brain and form an invasion complex with the endothelial cells of the co-opted vessels. The purpose of the present research was to elucidate the molecular mechanisms underlying the formation of the invasion complex and to develop a new anti-invasion therapy. Using a mouse GBM model, we identified the factors that determine the endothelial cells to participate in the formation of the invasion complex. Furthermore, by evaluating the anti-invasion potential of various classes of drugs using the brain slice culture assay, we found that inhibiting energy production can drastically reduce the invasion of glioma stem cells. We are now testing the most effective metabolic inhibitors in combination with chemotherapeutic agents in several animal models of glioma.

Free Research Field

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