Development of diagnostic technology for establishment of tailor-made prosthodontic treatments

2016 Fiscal Year Final Research Report

• Project/Area Number: 25253102
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Yatani Hirofumi 大阪大学, 歯学研究科, 教授 (80174530)
• Co-Investigator(Kenkyū-buntansha): 江草 宏 東北大学, 歯学研究科(研究院), 教授 (30379078) ; 加藤 隆史 大阪大学, 歯学研究科(研究院), 講師 (50367520) ; 萱島 浩輝 大阪大学, 歯学研究科(研究院), 助教 (50632121) ; 峯 篤史 大阪大学, 歯学研究科(研究院), 助教 (60379758)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: テーラーメイド医療

Outline of Final Research Achievements

In physiological approach, human and animal studies suggest that sympathetic tone and stress can play roles in the intra-individual fluctuation of sleep bruxism activity while age/development and behavioral characteristics can be a contributing factor for the intra-individual difference of masticatory muscle activity during sleep. In cell biology approach, we aimed to find patient-dependent biological factors responsible for cluster failure of osseointegration in dental implants using patient-derived iPS cells. During the course of experiments, an efficient osteogenic induction protocol for iPS cells was established. In regard to a material science approach, the material-human interface with the individual difference of tooth was evaluated. In consideration of individual differences of teeth as a random effect, the adhesion position, the void existence at interface and the adhesion area size were detected as a significant factor for bond strength by the liner mixed effect model.

Free Research Field

歯科補綴学