Study on the effects of development exposure to organic brominated flame retardants on obesity.

2017 Fiscal Year Final Research Report

• Project/Area Number: 25281033
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental impact assessment
• Research Institution: National Institute for Environmental Studies
• Principal Investigator: Yanagisawa Rie 国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (70391167)
• Co-Investigator(Kenkyū-buntansha): 小池 英子 国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 室長 (60353538) ; Tin・Tin Win・Shwe 国立研究開発法人国立環境研究所, 環境健康研究センター, 主任研究員 (00391128)
• Co-Investigator(Renkei-kenkyūsha): Win-Shwe Tin-Tin 国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (00391128)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: 肥満症 / 難燃剤 / 小児・次世代影響 / 内分泌かく乱

Outline of Final Research Achievements

Brominated flame retardants (BFRs) are widely used in many consumer products and have been found as environmental pollutants. Although BFRs can disrupt the endocrine, nervous and immune systems, the association between BFRs and obesity remains unclear. Thus, our current study investigated the effects of exposure to BFRs from fetal to adult using obese mouse model. As are results, 1) exposure to decabromodiphenyl ether (decaBDE) from childhood to adult enhanced diet-induced hyperglycemia through disruption of glucose homeostasis, 2) in utero and lactational exposure to hexabromocyclododecane (HBCD) facilitated diet-induced hyperglycemia in female offspring, but not male offspring, and 3) exposure of BFRs (decaBDE or HBCD) in the co-culture system of macrophages and adipocytes increased the production of CCL2/MCP-1 and TNF-α in a dose-dependent manner. From our study, it is suggested that exposure to low doses of BFRs may enhance obesity-related health problems

Free Research Field

環境毒性学