Molecular basis of metabolic physiology of C1-microorganisms and its application in methanol economy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25281063
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Design and evaluation of sustainable and environmental conscious system
• Research Institution: Kyoto University
• Principal Investigator: YURIMOTO Hiroya 京都大学, (連合)農学研究科(研究院), 准教授 (00283648)
• Co-Investigator(Renkei-kenkyūsha): SAKAI Yashuyoshi 京都大学, 大学院農学研究科, 教授 (60202082) ; OKU Masahide 京都大学, 大学院農学研究科, 助教 (10511230)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: メタノール資化性酵母 / 転写因子 / C1化合物代謝 / メタン / メタノール / ホルムアルデヒド / 硝酸 / メチルアミン

Outline of Final Research Achievements

For the purpose of development of novel biotechnology that can be applied in low carbon society “methanol economy”, we have studied molecular basis of metabolic physiology of C1-microorganisms that can utilize C1 compounds, such as methane and methanol, and its application. We focused on two major useful traits of methylotrophic yeasts, “strong methanol-inducible gene expression” and “ability to proliferate at the phyllosphere”. For example, molecular function of the transcriptional factor complex responsible for methanol-inducible gene expression was elucidated. Furthermore, we revealed nitrogen utilization and its regulation of the methylotrophic yeast at the phyllosphere.

Free Research Field

応用微生物学