Effect of new ellagitannin, Zeylaniin A, on lifestyle related disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 25282020
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Toita Women’s College (2015); Ochanomizu University (2013-2014)
• Principal Investigator: Otsuka Yuzuru 戸板女子短期大学, その他部局等, 教授 (20135833)
• Co-Investigator(Kenkyū-buntansha): SHINDO Kazutoshi 日本女子大学, 家政学部, 教授 (80350180) ; UETA Etsuko 鳥取大学, 医学部, 講師 (40335526) ; NOMI Yuri 新潟薬科大学, 応用生命科学部, 助教 (20614887) ; YAMAGUCHI Keiko 日本女子大学, 家政学部, 助教 (00440074)
• Co-Investigator(Renkei-kenkyūsha): MIHARA Hitomi 戸板女子短期大学, 食物栄養科, 助手 (20774631)
• Research Collaborator: SHIBAMOTO Takayuki University of California Davis, Department of Environmental Toxicology, Distinguished Professor
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 新規ポリフェノール / Zeylaniin A / Tram / ベトナム植物 / AGE / 抗酸化 / LC-MS/MS / 糖尿病

Outline of Final Research Achievements

New polyphenol Zeylaniin A was purified from Vietnam edible plant Tram, and analyzed biological function on life style related disease. S.zeylanicum leaf was obtained from Dr. Mai of Vietnam National Nutritional Institute. Purified Zeylaniin A recovered UVA damaged cell. Zeylaniin A was added to animal feed and measured glucose and AGEs. Blood glucose of Zeylaniin A group was 320 mg/dl and showed no difference to control. New method for AGE analysis was developed with new column. Blood CEL was 73-129ng/mL and MG-H1 was 38-184ng/mL, and average of blood CEL of Zeylaniin A group was 104ng/ml. There was no significant difference between Zeylaniin A group and control group.

Free Research Field

分子栄養学