2016 Fiscal Year Final Research Report
Elucidation of Na+ recycling mechanisms induced by Na-dependent nutrient absorption in the small intestine
| Project/Area Number |
25282024
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
五十里 彰 岐阜薬科大学, 薬学部, 教授 (50315850)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | Na依存性栄養素吸収 / タイト結合 / クロージン / 陽イオン透過性 |
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| Outline of Final Research Achievements |
Many nutrients are absorbed by Na-dependent transport mechanisms in the small intestine. However, little is known about how the intestine meet the needs of Na for nutrient absorption. It is thought that Na diffuses back into the lumen via paracellular pathways to support nutrient absorption. However, direct experimental evidence in support this idea has not been shown. To investigate whether paracellular pathways are involved in this Na recycling, we measured glucose-induced currents and 22Na fluxes simultaneously in Ussing chambers. We found that Na which is absorbed into enterocytes is rapidly recycled back into the lumen via paracellular pathways which are driven by increased luminal negativity.
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| Free Research Field |
消化管の生理学
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