Establishment of elemental techniques for magnetic particle imaging aiming at application to nanoparticle medicine

2017 Fiscal Year Final Research Report

• Project/Area Number: 25282131
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: Kenya Murase 大阪大学, 医学系研究科, 教授 (50157773)
• Co-Investigator(Kenkyū-buntansha): 吉岡 芳親 大阪大学, 先導的学際研究機構, 教授 (00174897) ; 木村 敦臣 大阪大学, 医学系研究科, 准教授 (70303972) ; 岩崎 智宏 大阪府立大学, 工学(系)研究科(研究院), 准教授 (50295721) ; 白土 優 大阪大学, 工学(系)研究科(研究院), 准教授 (70379121)
• Research Collaborator: TAKATA Hiroshige ; TAKEUCHI Tomoki
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: ナノ粒子メディスン / 磁気粒子イメージング / 磁気温熱療法 / 磁気送達法 / 温度感受性リポソーム / 細胞追跡法

Outline of Final Research Achievements

In recent years, an imaging method called magnetic particle imaging (MPI) method has attracted attention, which allows imaging of magnetic nanoparticles (MNPs). In order to put this method into practical use, it is indispensable to establish elemental technologies related to high resolution and high sensitivity. Therefore, we developed a data acquisition method and an image reconstruction method to visualize the distribution of MNPs with high resolution based on the existing MPI device and investigated the effectiveness of them by phantom experiments etc. We also searched the characteristics of MNPs for realizing MPI with high resolution and high sensitivity. Furthermore, we developed contrast agents for MPI, in which MNPs are encapsulated into erythrocytes or liposomes, and performed animal experiments using tumor-bearing mice. As a result, it was made clear that our method is useful and can be applied to nanoparticle medicine.

Free Research Field

医用生体工学