Development of titanium with ex vivo antibacterial activity and in vivo osteoconductivity

2015 Fiscal Year Final Research Report

• Project/Area Number: 25282139
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: Kawashita Masakazu 東北大学, 医工学研究科, 准教授 (70314234)
• Co-Investigator(Kenkyū-buntansha): KANETAKA Hiroyasu 東北大学, 大学院歯学研究科, 准教授 (50292222)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: チタン / 窒素 / 可視光応答光触媒 / 抗菌性 / 生体活性

Outline of Final Research Achievements

Ti treated with NaOH, hot water, and heated in an ammmonia gas atmosphere for 1 or 3 h showed in vitro apatite formation within 7 days when soaked in simulated body fluid (SBF). The treated Ti decomposed methylene blue and showed excellent bactericidal activity against Escherichia coli under visible light irradiation. A fine network of N-doped anatase-type titania (TiO2-xNx) formed on the Ti surface due to the surface treatment and was responsible for both the apatite formation in SBF and the visible-light induced antibacterial activity. These preliminary results suggest a simple method for producing novel bioactive Ti with visible light-induced antibacterial activity, which can be applied in orthopaedic and dental implants without the risk of infection.

Free Research Field

生体材料学