Development of three dimensional dose evaluation system using prompt gamma-ray for boron neutron capture therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 25282155
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Kyoto University
• Principal Investigator: Tanaka Hiroki 京都大学, 原子炉実験所, 准教授 (70391274)
• Co-Investigator(Kenkyū-buntansha): 櫻井 良憲 京都大学, 原子炉実験所, 准教授 (20273534) ; 川端 信司 大阪医科大学, 医学部, 講師 (20340549)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ホウ素中性子捕捉療法 / リアルタイムホウ素濃度測定 / がん治療 / 線量評価システム / SPECT

Outline of Final Research Achievements

Generally, boron concentration is measured by the method of prompt gamma ray analysis in BNCT treatment. However, the information of boron concentration is not able to be obtained by this method during the treatment. It is desired to measure the boron concentration in real-time. Therefore, we propose the method using prompt gamma rays with the energy of 478 keV emitted by the reaction between boron-10 and thermal neutron. There are some agendas, which should be overcome in order to apply a prompt gamma rays imaging detector in BNCT irradiation field. Most important agenda is the discrimination from 511 keV annihilation gamma ray as back-ground. The energy resolution of less than 6.5 % FWHM at 511 keV is needed in order to discriminate 511 keV gamma ray.
We constructed a prompt gamma rays imaging detector consisting of LaBr3(Ce) scintillator, 8 x 8 MPPC arrays, 64 channel channels amplifier and ADC. It was confirmed that this system was able to discriminate 511 keV gamma ray.

Free Research Field

医学物理学