2015 Fiscal Year Final Research Report
The role of microRNAs in mechanical stress-induced muscle adaptation
| Project/Area Number |
25282198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKIMOTO Takayuki 東京大学, 医学(系)研究科(研究院), 講師 (00323460)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 筋線維タイプ / 転写後制御 / ノンコーディングRNA / 可塑性 / メカニカルストレス |
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| Outline of Final Research Achievements |
We investigated the role of microRNA on mechanical stress-induced muscle adaptation by using Dicer1 knock-out mice (Dicer1 KO). As a result, the muscle-specific Dicer1KO mice died by 6 weeks due to dysfunction of muscles, suggesting that microRNAs in muscle play important roles in homeostasis of muscles.
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| Free Research Field |
筋生物学
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