Elucidation of the mechanisms of skeletal muscle hypertrophy by intracellular calcium concentration.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25282202
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: TAKEDA SHIN'ICHI 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 部長 (90171644)
• Co-Investigator(Kenkyū-buntansha): SUZUKI YUUKO 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患 治療研究部, 室長 (00342931) ; AOKI YOSHITSUGU 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 室長 (80534172)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 筋肥大 / 筋萎縮 / カルシウム / nNOS / NO / ATP / P2Y / IP3R

Outline of Final Research Achievements

Skeletal muscle atrophy occurs in ageing, and several pathological conditions including cancer, renal failure, AIDS, sepsis and diabetes. We aim to elucidate the molecular mechanisms of muscle hypertrophy by focusing on the intracellular calcium concentration, which will lead to the development of novel therapy for muscle atrophy. As a results, we elucidated that extracellular ATP promoted muscle hypertrophy by increasing intracellular calcium concentration and subsequent activation of mTOR and MAPK.

Free Research Field

骨格筋筋肥大・筋萎縮