Fasting-induced transcription factor CREBH ameliorates obesity via entero-hepatic circulation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25282214
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: Nakagawa Yoshimi 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80361351)
• Co-Investigator(Kenkyū-buntansha): Shimano Hitoshi 筑波大学, 医学医療系, 教授 (20251241) ; Matsuzaka Takashi 筑波大学, 医学医療系, 准教授 (70400679)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 生活習慣病 / CREBH / ゲノム編集 / 肥満 / 糖尿病

Outline of Final Research Achievements

CREBH is a transcription factor, which is expressed in liver and intestine. Liver-specific CREBH Tg mice were generated, which suppressed diet-induced obesity and diabetes. CREBH and PPARα synergistically regulated hepatic FGF21 expression. CREBH KO mice showed atherosclerosis and non-alcoholic fatty liver disease. Conversely, CREBH Tg suppressed atherosclerosis. Using CRISPR/Cas9 system, we firstly generated liver-specific CREBH knockout mice, which exhibited non-alcoholic fatty liver disease, suggesting that liver CREBH, but not intestine CREBH, is important for the pathology of non-alcoholic fatty liver disease

Free Research Field

栄養学