2016 Fiscal Year Final Research Report
A study for elucidating mechanisms underlying preventive effects of physical activity/exercise training on colon cancer
| Project/Area Number |
25282219
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Tabata Izumi 立命館大学, スポーツ健康科学部, 教授 (20188402)
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| Research Collaborator |
Matsuo Kaori
Sato Koji
Higashida Kazuhiko
Miyamoto Eri
Iemitsu Motoyuki
Hamaoka Takahumi
Suemoto Ken
Tsuji Katsunori
Xu Yuzhong
Liu Xin
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 大腸がん / 身体活動 / 運動トレーニング / ACF / SPARC |
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| Outline of Final Research Achievements |
By conducting experiments inculuding in vitro study to human training study, we found a mehanism underlying preventive effects of exercise training, especially high intensity intermittent exercise training, on colon cancer development as folows.
First, high intensity intermittent exercise elevated AMPK whose activitiy is exercise-intensity dependent, Second, AMPK activation enahces PGC1α expression in exercised muscle. Third, PGC1αinduced SPARC protein. Forth, this increased expression of SPARC elvated its serum concentrataion after exercise.The incrased concentration of SPARC which is kwnon to induce aptosis of pre-cancer cell of ACF in colon may reduce risk of developing colon cancer.
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| Free Research Field |
スポーツ健康科学
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